Name | ORY-1001 |
Synonyms | RG6016 RG 6016 RG-6016 ORY1001 ORY 1001 ORY-1001 LSD1-IN-1 ORY-1001 (RG-6016) ORY-1001 2HCl salt ORY-1001(IADADEMSTAT) ORY-1001 trans and cis isomers |
CAS | 1431326-61-2 |
Molecular Formula | C15H24Cl2N2 |
Molar Mass | 303.27046 |
Solubility | DMSO: < 6.8 mg/mL |
Storage Condition | -20℃ |
In vitro study | In THP-1 (MLL-AF9) cells, ORY-1001 resulted in a time/dose-dependent accumulation of me2H3K4 at the KDM1A target gene while inducing differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits the proliferation and colony formation of MV(4;11) (MLL-AF4) cells. |
In vivo study | In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) resulted in a significant reduction in tumor growth. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.297 ml | 16.487 ml | 32.974 ml |
5 mM | 0.659 ml | 3.297 ml | 6.595 ml |
10 mM | 0.33 ml | 1.649 ml | 3.297 ml |
5 mM | 0.066 ml | 0.33 ml | 0.659 ml |